Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9422682 | Brain Research Protocols | 2005 | 5 Pages |
Abstract
As an index of oxidative status, we analyzed ascorbyl radical generation during and after kainate-induced seizures in mouse hippocampus, using an ESR spectrometer equipped with a special tissue-type quartz cell. A specific doublet ESR spectrum was observed after seizures, and the g value and the hyperfine coupling constant (hfcc) of the spectrum were identical with those of ascorbyl radical itself. Antiepileptic zonisamide inhibited the generation of ascorbyl radical accompanying the seizures.
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Authors
Toshiki Masumizu, Yasuko Noda, Akitane Mori, Lester Packer,