Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9423041 | Brain Research Reviews | 2005 | 13 Pages |
Abstract
Oxidative stress is thought to play a role in the onset of dementia. HIV-dementia has recently been demonstrated to be associated with oxidative stress as indexed by increased protein and lipid peroxidation in the brain and cerebrospinal fluid compared to HIV non-demented patients. The HIV protein Tat induces neurotoxicity, and, more recently, Tat was found to induce oxidative stress directly and indirectly. The role of Tat in HIV-dementia and possible therapeutic strategies involving endogenous and exogenous antioxidants are discussed.
Keywords
HNEiNOSEGCGNACGSHIP3PLCPKCinositol triphosphateLRPQUINTrxTricyclodecan-9-yl-xanthogenateD609TNF4-hydroxy-2-nonenalN-acetylcysteineROSAntioxidantApoeapolipoprotein EDisorders of the nervous systemQuinolinic acidepigallocatechin gallateinterleukinAlzheimer's diseaseInfectious diseasesTATOxidative stressthioredoxinCNSdiacylglycerolDAGinducible nitric oxide synthasecentral nervous systemendoplasmic reticulumtumor necrosis factorphosphatidylinositolphospholipase CLow-density lipoproteinCerebrospinal fluidCSFNitric oxidehuman immunodeficiency virusHIVProtein kinase CGlutathioneReactive oxygen species
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Authors
Chava B. Pocernich, Rukhsana Sultana, Hafiz Mohmmad-Abdul, Avindra Nath, D. Allan Butterfield,