Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9423080 | Brain Research Reviews | 2005 | 11 Pages |
Abstract
Morphogen signalling among cells is one of the most important mechanisms underlying the progressive patterning of embryos. Members of the hedgehog (Hh), wingless (Wnt), transforming growth factor-β (TGFβ), and fibroblast growth factor (Fgf) families of extracellular signalling molecules act as morphogens. Recent studies have demonstrated that members of these four families of proteins, secreted by well-characterised organiser centres in the central nervous system (CNS) as floor plate or midbrain-hindbrain boundary, are reused at later developmental stages to control axon growth. Here, we have summarised the evidence for this novel idea with a particular emphasis on those related to Shh and Wnt signalling-the object of some works in our laboratory.
Keywords
PKCinositol 1,4,5 triphosphateCyclic nucleotide-gated ion channelsCommissural axonNF-ATFGF8frizzledPKGGSK3βPLCIP3CaMKIIDVLPDETFsMTSβ-catenindishevelledDevelopment and regenerationShhdiacylglycerolDAGWnt signallingNuclear Factor of Activated T CellsTranscription factorsPhosphodiesterasephospholipase CBMPAxon guidance mechanisms and pathwaysMicrotubulesMicrotubule-associated protein 1Bprotein kinase GProtein kinase CGlycogen synthase kinase 3β
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Authors
Cristina Sánchez-Camacho, Josana RodrÃguez, José MarÃa Ruiz, Françoise Trousse, Paola Bovolenta,