| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 9423868 | Current Opinion in Neurobiology | 2005 | 7 Pages |
Abstract
Following the gradual recognition of the importance of intracellular calcium stores for somatodendritic signaling in the mammalian brain, recent reports have also indicated a significant role of presynaptic calcium stores. Ryanodine-sensitive stores generate local, random calcium signals that shape spontaneous transmitter release. They amplify spike-driven calcium signals in presynaptic terminals, and consequently enhance the efficacy of transmitter release. They appear to be recruited by an association with certain types of calcium-permeant ion channels, and they induce specific forms of synaptic plasticity. Recent research also indicates a role of inositoltrisphosphate-sensitive presynaptic calcium stores in synaptic plasticity.
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Authors
Thibault Collin, Alain Marty, Isabel Llano,