| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 9425475 | Neuroscience | 2005 | 10 Pages |
Abstract
These results imply that synaptic plasticity in response to chronic striatal dopamine depletion involves a complex pattern of changes in striatal Syt mRNA expression. The l-DOPA treatment does not reverse the changes in Syt II and Syt X gene expression, but recruits additional, D1 receptor-mediated changes in Syt IV and Syt VII gene expression. Whether these D1 receptor-mediated changes play a role in the alterations of synaptic transmission that results in the unwanted side effects of chronic l-DOPA treatment in Parkinson's disease remains to be determined.
Keywords
SKF829586-OHDAPPT6-HydroxydopamineSNCRODSNRsynaptotagminsSubstantia nigra pars reticulataVTAProenkephalinSCH23390In situ hybridizationl-DOPAStriatumanalysis of varianceANOVArelative optical densitysubstantia nigra pars compactatyrosine hydroxylaseSynaptotagminventral tegmental areaPreprotachykininPENKSYT
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Authors
G. Glavan, M. Zivin,