Effect of N-methyl-d-aspartate receptor blockade on neuronal plasticity and gastrointestinal transit delay induced by ischemia/reperfusion in rats

Article ID	Journal	Published Year	Pages	File Type
9425528	Neuroscience	2005	11 Pages	PDF

Abstract

This study suggests an involvement of the glutamatergic system and its interaction with nitric oxide in intestinal ischemia/reperfusion. Ischemia/reperfusion might induce local release of glutamate that activates N-methyl-d-aspartate receptors leading to increased production of nitric oxide and adaptive changes in enteric transmitters that might contribute to gastrointestinal dysmotility.

Keywords

PBS FITC N-nitro-l-arginine NMDA-R VIP S.E.M.nNOS MK-801 l-NAME phosphate buffer Saline Phosphate buffer standard error mean SO2 neuronal nitric oxide synthase fluorescein isothiocyanate Substance P Descending pathway Nitric oxide Vasoactive intestinal polypeptide N-Methyl-d-aspartate receptors