| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 9425748 | Neuroscience | 2005 | 14 Pages |
Abstract
The observed changes suggest substantial and cell specific rearrangement of GABA receptors. Lasting downregulation of subunits δ and α5 in granule cells and transient decreases in subunit α2 and β1-3 mRNA levels in cornu ammonis 3 pyramidal cells are suggestive of impaired GABAA receptor-mediated inhibition. Persistent upregulation of subunits β1-3 and γ2 of the GABAA receptor and of GABABR2 mRNA in granule cells, however, may result in activation of compensatory anticonvulsant mechanisms.
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Authors
T. Nishimura, C. Schwarzer, E. Gasser, N. Kato, A. Vezzani, G. Sperk,