| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 9425776 | Neuroscience | 2005 | 11 Pages |
Abstract
In conclusion, our results, reporting modifications of PPARs, RXRs, C/EBPs and β-catenin during culture time, strongly suggest the involvement of these transcription factors in astrocyte differentiation. Specifically, β-catenin translocation from the nucleus to plasma membrane, together with PPARβ/δ decrease and C/EBPα increase, could be related to decreased proliferation at confluence, while PPARα and γ and all C/EBPs could participate in differentiation processes, such as glycogenesis and lipidogenesis.
Keywords
TBSPCNARXRPLLRetinoid X receptorTTBSFCSPPARGFAPPBSFITCSDSBSAC/EBPbovine serum albuminProliferating Cell Nuclear AntigenEDTAEthylenediaminetetraacetic acidTris-buffered salineDifferentiationRoom temperatureDIVdays in vitrosodium dodecyl sulfatefetal calf serumStem cellsTranscription factorsPhosphate buffered salinefluorescein isothiocyanateLipidBrainCCAAT/enhancer binding proteinGlial fibrillary acidic proteinPoly-l-lysineGlycogenperoxisome proliferator-activated receptor
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Authors
L. Cristiano, A. Cimini, S. Moreno, A.M. Ragnelli, M. Paola Cerù,