Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9426412 | Neuroscience | 2005 | 13 Pages |
Abstract
These data demonstrate that non-Ang II [125I] CGP42112 binding following nodose ganglionectomy is attenuated by minocycline treatment. This minocycline-induced effect was associated with reduced activation of microglia and an apparent reduction in the number of macrophages in the abovementioned nuclei. This evidence suggests that a non-Ang II [125I] CGP42112 binding site is located on, or associated with, activated microglia and macrophages, providing a useful tool with which to quantitate the neuroprotective effects of centrally acting anti-inflammatory compounds.
Keywords
DMXPBRReactive gliaNTSAT2MCIDWKYAngiotensin IIAutoradiographyinflammationImmunohistochemistryanalysis of varianceANOVAmicrocomputer imaging deviceAng IINeuronal degenerationN.Ambnucleus ambiguusnucleus of the solitary tractDorsal motor nucleus of the vagus nerveWistar Kyotoperipheral benzodiazepine receptor
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Authors
C.L. Roulston, A.J. Lawrence, R.E. Widdop, B. Jarrott,