| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 9428880 | Neuroscience Letters | 2005 | 5 Pages |
Abstract
The characteristic folial pattern of the mouse cerebellum is formed during postnatal development. We observed this process in C57BL/6J (B6) mice in detail, and found an abnormal folial pattern in a specific region (lobules VIII and IX of the vermis) in a substantial number of B6 mice. The frequency of this abnormality increased during postnatal development and reached 55% in the adult. Thus, the present study showed an abnormality in the cerebellar folial pattern of B6 mice, a mouse widely used in knockout studies, and called for caution in the phenotypic analysis of knockout mice of the B6 genetic background.
Related Topics
Life Sciences
Neuroscience
Neuroscience (General)
Authors
Masahiko Tanaka, Tohru Marunouchi,