Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9429324 | Neuroscience Letters | 2005 | 5 Pages |
Abstract
Maternal alcohol consumption during pregnancy is known to have a detrimental effect on the development of the fetus and its central nervous system (CNS) in particular. In the present study, the dose-dependence of the effect of maternal alcohol on hippocampal c-Fos expression, which is a marker of hippocampal neuronal activity and which is induced by a variety of stimuli, was examined in infant rats. In the present study, it was shown that expression of c-Fos in the hippocampus is decreased following treatment with alcohol in a dose-dependent fashion. Based on the results of the present study and the findings of other studies, it can be suggested that suppression of c-Fos expression in the hippocampus of infant rats with maternal alcohol administration mediates the associated developmental retardation and/or anomalies.
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Authors
Mi-Hyeon Jang, Sae-Bin Jung, Myoung-Hwa Lee, Hong Kim, Sam-Jun Lee, Young-Je Sim, Hee-Hyuk Lee, Eun-Kyung Kim, Chang-Ju Kim, Hye-Sook Shin, Jeongseon Kim, Ee-Hwa Kim,