Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9429330 | Neuroscience Letters | 2005 | 4 Pages |
Abstract
Serotonin (5-HT) is a neurotransmitter and an immune modulator. At the periphery, the serotonergic system appears to possess a regulatory activity via 5-HT1B receptors. The present study investigated the effects of a 5-day military course following 3 weeks of combat training on the functional activity of 5-HT1B/1D receptors in peripheral blood lymphocytes of male soldiers. The results of [35S]GTPγS binding assays showed that h5-HT1B/1D receptors were desensitized after the training program, although serum 5-HT was unchanged. These data suggest the existence of a control on T cells mediated through h5-HT1B/1D receptors leading cytokine production modulation after a physical training.
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Authors
M. Chennaoui, C. Drogou, D. Gomez-Merino, C.Y. Guezennec,