| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 9429672 | Neuroscience Letters | 2005 | 4 Pages |
Abstract
The present study investigated the alteration in intracerebroventricular administration of substance P-induced anti-nociception after morphine tolerance in rats. The nociceptive response latencies to noxious thermal and mechanical stimulation increased significantly after intracerebroventricular administration of SP in normal rats. The SP-induced anti-nociception decreased significantly in morphine-tolerant rats than that in opioid naïve rats. The results demonstrated that SP induced significant anti-nociceptive effects in the brain in normal rats, and the SP-induced anti-nociception was attenuated significantly in morphine-tolerant rats than that in opioid naïve rats, indicating an alteration in SP-induced anti-nociception in the brain after chronic morphine treatments.
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Neuroscience (General)
Authors
Xiao-Guo Dong, Long-Chuan Yu,