| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 9434411 | Neuroscience Research | 2005 | 7 Pages |
Abstract
The differential expression of AMPA receptor subunit mRNA was analyzed in the adult rat brain and spinal cord using quantitative RT-PCR with laser capture microdissection. The expression of all four AMPA receptor subunits was demonstrable, with the mRNA expression level for GluR2 being the highest in all the brain areas and neuronal subsets examined. Both the absolute expression level of GluR2 mRNA and its expression relative to the other subunits were the lowest in motoneurons. The unique AMPA receptor expression profile of motoneurons may render them selectively vulnerable to AMPA receptor-mediated excitotoxicity.
Keywords
AMPASPWCerebellar Purkinje cellsα-amino-3-hydroxy-5-methyl-4-isoxazole propionic acidPurkinjeGluR2Dorsal funiculusquantitative RT-PCRamyotrophic lateral sclerosisexcitotoxicityALSSensorycerebellar granule cellsVentral funiculuscerebral cortexCerebral white matterCerebellummotorSpinal motoneuronsCblGranuleAMPA receptor
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Authors
Hui Sun, Yukio Kawahara, Kyoko Ito, Ichiro Kanazawa, Shin Kwak,