Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9434472 | Neuroscience Research | 2005 | 13 Pages |
Abstract
Our results demonstrated that G6PD, P450R and GR have a similar distribution pattern characterized by the highest concentration of these enzymes in the somata of Purkinje cells, and by lower concentrations in the molecular and the granule cell layers. Moreover, in Purkinje cells, G6PD colocalized with both P450R and GR. NADPH-d activity showed a different distribution pattern when compared to the other enzymes, revealing the highest activity in the molecular layer and the lowest in Purkinje cells. Our results suggest a coordinated regulative mechanism of G6PD, P450R and GR based on the request of NADPH or on specific transcription factors.
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Neuroscience
Neuroscience (General)
Authors
Paola Ferri, Enrica Biagiotti, Patrizia Ambrogini, Spartaco Santi, Paolo Del Grande, Paolino Ninfali,