Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9435149 | Progress in Neurobiology | 2005 | 20 Pages |
Abstract
The last 30 years have witnessed tremendous progress in elucidating the basic mechanisms underlying a simple form of olfactory learning and memory in Drosophila. The application of the mutagenic approach to the study of olfactory learning and memory in Drosophila has yielded insights into the participation of a large number of genes in both the development of critical brain regions as well as in the physiology underlying the acquisition, storage, and retrieval of memory. Newer sophisticated molecular-genetic tools have further allowed for the specification and functional dissection of the neuronal circuitry involved in these processes at a systems level. With these advances in our understanding of the genes, neurons, and circuits involved in learning and memory, the field of Drosophila memory research is nearing a state of integration of the bottom up and top down approaches to understanding this form of behavioral plasticity.
Keywords
CREBARMSPHANPERKUASSTMACTALAPTPMBMEMSLTMASMCaMKIIpKaNMJPACAPLFPPKCNF1mEPSCMCHEYFPMBDdpmAge-related memory impairmentCPEBSynapsinsAMNDSCR1MARCMmosaic analysis with a repressible cell markerMTMDNCLEOECFPORNsRUTGBBOmnipause neuronsRSHFasciclin IIRutabagaAmIcAMPDNAMAPKCyclic adenosine monophosphatephospholipase A2AChNeuromuscular junctionEthyl methane sulfonateStaufenAcetylcholinedeoxyribonucleic acidRNAribonucleic acidgamma amino butyric acidenhanced cyan fluorescent proteinFluorescent Resonance Energy TransferFRETOctmushroom bodyBenzaldehydeRadishminiature excitatory post-synaptic currentVolLong Term MemoryShort term memoryDORupstream activating sequencedunceBehaviorLATCerKenyon cellDown's syndromeSynLeonardostauunconditioned stimulusconditioned stimulusBMPIACTDrosophila melanogasterNlaFASIINeurofibromatosis 1Projection neuronsOlfactory receptor neuronsNotchlocal field potentialPost-tetanic potentiationcytoplasmic polyadenylation element binding proteincAMP response element binding proteinenhanced yellow fluorescent proteinbone morphogenic proteinprotein kinase AProtein kinase Cmitogen activated protein kinasePUMPumilioPituitary adenylyl cyclase activating peptideChATcholine acetyltransferaseextracellular signal-regulated kinaseGABAGal4
Related Topics
Life Sciences
Neuroscience
Neuroscience (General)
Authors
Sean E. McGuire, Mitch Deshazer, Ronald L. Davis,