Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9436480 | Hearing Research | 2005 | 6 Pages |
Abstract
To investigate the effects of the tinnitus inducer sodium salicylate on L-type voltage-gated calcium channels, we studied freshly dissociated inferior colliculus neurons of rats by the whole-cell voltage clamp method. Salicylate's blocking of L-type calcium channels was concentration dependent, and the IC50 value of salicylate was estimated to be 1.99Â mM. An amount of 1Â mM salicylate significantly shifted the steady-state inactivation curve of L-type calcium channels about 9Â mV in the hyperpolarizing direction and significantly delayed calcium channel recovery. Our results suggest that salicylate's blocking of L-type calcium channels may contribute to salicylate-induced tinnitus by decreasing GABA release in the inferior colliculus.
Keywords
Related Topics
Life Sciences
Neuroscience
Sensory Systems
Authors
Yanxing Liu, Xuepei Li, Changsheng Ma, Junxiu Liu, Hong Lu,