Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9442591 | Experimental Parasitology | 2005 | 5 Pages |
Abstract
To investigate the role of clathrin-mediated trafficking during the Leishmania lifecycle, open reading frames encoding clathrin heavy chain and the β-adaptins, major components of the adaptor complexes, have been analysed both in silico and experimentally. The Leishmania genome encodes three β-adaptins, which arose at a time predating speciation of these divergent trypanosomatids. Unlike Trypanosoma brucei, both clathrin heavy chain and β-adaptin1 are constitutively expressed throughout the Leishmania life cycle. Clathrin relocalises in amastigotes relative to promastigotes, consistent with developmental alterations to the morphology of the endo-membrane system.
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Authors
Paul W. Denny, Gareth W. Morgan, Mark C. Field, Deborah F. Smith,