Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9573247 | Biophysical Chemistry | 2005 | 11 Pages |
Abstract
The frequency of free cytosolic calcium concentration ([Ca2+]) oscillations elicited by a given agonist concentration differs between individual hepatocytes. However, in multicellular systems of rat hepatocytes and even in the intact liver, [Ca2+] oscillations are synchronized and highly coordinated. In this paper, we have investigated theoretically the effects of gap junction permeable to calcium and of the total Ca2+ channel number located on endoplasmic reticulum on intercellular synchronization. Figures of ratio between mean oscillating frequency of coupled cells describe visually the process of phase-locking. By virtue of a set of phase analysis, we can observe a gradual transition from synchronous behavior to nonsynchronous behavior. Furthermore, a signal-to-noise ratio in two dimensional parameter space (coupling strength-total Ca2+ channel number) has suggested that, coherence resonance will occur for appropriate noise and coupling.
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Physical Sciences and Engineering
Chemistry
Physical and Theoretical Chemistry
Authors
Dan Wu, Ya Jia, Lijian Yang, Quan Liu, Xuan Zhan,