| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 9573348 | Biophysical Chemistry | 2005 | 6 Pages |
Abstract
Danthron is an important natural occurring component in laxative drugs. In this paper, electrochemical investigation of danthron and its interaction with DNA is reported. Via the electrochemical approach assisted by ultraviolet-visible (UV-Vis) spectroscopy, we have proved that danthron intercalates into DNA strands forming some nonelectroactive complexes, which results in the decrease of redox peak currents of danthron. In addition, the decrease of the peak currents is proportional to the concentration of DNA. The difference between the interaction of danthron with double-stranded DNA (dsDNA) and with single-stranded DNA (ssDNA) has also been studied. This character implies the potential of danthron to discriminate dsDNA and ssDNA.
Related Topics
Physical Sciences and Engineering
Chemistry
Physical and Theoretical Chemistry
Authors
Hui Zhou, Ziyi Sun, Tomonori Hoshi, Yoshitomo Kashiwagi, Jun-ichi Anzai, Genxi Li,