| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 9577444 | Chemical Physics Letters | 2005 | 5 Pages |
Abstract
The binding of chlorin p6 with Cremophor EL (CrEL) at pH 5 and pH 7 has been monitored by fluorescence techniques. Upon binding with the drug delivery agent, the fluorescent species are found to be one and the same at both pH values. This is explained by a hindrance to protonation of chlorin p6 trianions by Cremophor EL. Surprisingly, it is the more hydrophilic species between the two possible chlorin p6 ions that is found to get bound preferentially with the hydrophobic delivery medium.
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Authors
Sunita Patel, Anindya Datta,