Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9587358 | Journal of Magnetic Resonance | 2005 | 6 Pages |
Abstract
Deuterium site-specific natural isotope abundance (Ai) is routinely measured by NMR spectroscopy and quantified using an internal reference peak. This study demonstrates that the substitution of the chemical compound used as internal reference by an electronically generated signal (the ERETIC method) allows a dramatic reduction of the experimental time. Measurements of Ai on eight samples of methylsalicylate have been performed using either an internal reference (TMU) or ERETIC. No significant difference in accuracy or precision had been found between the two methods. However, because the method is applicable in partially saturated conditions, the experiment time was divided by a factor of 4 and the drawbacks associated with an internal chemical reference were avoided when ERETIC was used.
Related Topics
Physical Sciences and Engineering
Chemistry
Physical and Theoretical Chemistry
Authors
Flore Le Grand, GĂ©rard George, Serge Akoka,