Interactions of transition metal ions with His-containing peptide models of histone H2A

In basic solutions, the peptides -TASHHK- and -TESAHK- were hydrolyzed in a Ni(II)-assisted fashion, while no hydrolytic processes were noticed in peptides -TEAHHK- and -TESHAK- where the Ser or His-5 residues are replaced with the Ala residue. Moreover, CuH−1L complex with -TESHHK- reacts with H2O2 and the resulting reactive oxygen intermediate efficiently oxidizes 2′-deoxyguanosine.