Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9591713 | Journal of Molecular Structure: THEOCHEM | 2005 | 6 Pages |
Abstract
In this paper, the topological molecular descriptors were introduced to the QSAR studies of three types of 20(S)-camptothecin analogues and good relationships between the biological activity and the descriptors of the substitutions of those compounds were obtained with multiple regression. These QSAR models have good predictive ability, which will be of great benefit to our future design and synthesis of novel highly potent antitumor camptothecin analogues and be helpful for proving or improving the action mechanism supposed.
Related Topics
Physical Sciences and Engineering
Chemistry
Physical and Theoretical Chemistry
Authors
Min-Jie Li, Chen Jiang, Ming-Zong Li, Tian-Pa You,