Article ID Journal Published Year Pages File Type
9594199 Solid State Nuclear Magnetic Resonance 2005 11 Pages PDF
Abstract
Two diastereoisomeric chiral stationary phases (CSPs), devised for enantioselective HPLC, showing unexplained differences in their chromatographic performances, have been characterized, together with their soluble models, by means of 13C-cross polarization/magic angle spinning (CP/MAS), 1H-MAS and 1H-free induction decay (FID) analysis. The NMR investigation of the soluble models has not highlighted significant structural/conformational differences between the two diastereoisomers, but has constituted a useful support for the analysis of the more complex NMR data of the CSPs. The organic chiral selectors of the stationary phases show a poor internal mobility and no conformational differences between the two diastereoisomers have been observed. On the contrary, interesting differences between the two CSPs have been found involving the silanols on the silica surface and the dynamics of the linking chains between the organic selectors and the silica surface itself. An explanation of the chromatographic behaviour has been proposed in terms of different proximity of the organic moieties with respect to the inorganic surface in the two CSPs.
Related Topics
Physical Sciences and Engineering Chemistry Physical and Theoretical Chemistry
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