Article ID Journal Published Year Pages File Type
9614920 Journal of Molecular Catalysis A: Chemical 2005 8 Pages PDF
Abstract
The intramolecular CH insertion on α-diazoacetamides is an extremely useful procedure for the preparation of a wide variety of heterocyclic compounds. In this work is presented a strategy for the preparation of enantioselective enriched α-(dialkoxyphosphoryl)lactams via dirhodium(II) catalyzed CH insertion on α-diazo-α-(dialkoxyphosphoryl)acetamides, in which enantiomeric excess up to 40% is reported. Moreover, a systematic study was undertaken on the chiral dirhodium(II) catalyst and the α-diazo-α-(dialkoxyphosphoryl)acetamides influence on enantioselectivity.
Related Topics
Physical Sciences and Engineering Chemical Engineering Catalysis
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