Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9614920 | Journal of Molecular Catalysis A: Chemical | 2005 | 8 Pages |
Abstract
The intramolecular CH insertion on α-diazoacetamides is an extremely useful procedure for the preparation of a wide variety of heterocyclic compounds. In this work is presented a strategy for the preparation of enantioselective enriched α-(dialkoxyphosphoryl)lactams via dirhodium(II) catalyzed CH insertion on α-diazo-α-(dialkoxyphosphoryl)acetamides, in which enantiomeric excess up to 40% is reported. Moreover, a systematic study was undertaken on the chiral dirhodium(II) catalyst and the α-diazo-α-(dialkoxyphosphoryl)acetamides influence on enantioselectivity.
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Catalysis
Authors
Pedro M. P. Gois, Nuno R. Candeias, Carlos A.M. Afonso,