Article ID Journal Published Year Pages File Type
9622489 Forensic Science International 2005 10 Pages PDF
Abstract
MDMA was prepared by five different synthesis routes, i.e. by dissolving metal reduction (Al/Hg), cyanoborohydride reduction (NaBH3CN), borohydride reduction in low temperature (NaBH4), Leuckart reaction and safrole bromination. MDP-2-P was prepared by two different synthesis methods, i.e. by isosafrole oxidation and MDP-2-nitropropene reduction. Each of the synthesis routes was repeated three times in order to establish variation in qualitative composition of route specific impurities between different batches. The analysis of impurities in MDP-2-nitropropene, MDP-2-P, bromosafrole and MDMA was performed with GC-MS. GC/MS was used also in the analysis of impurities in starting materials: safrole, isosafrole and piperonal. As a result of our study the way of determination of MDMA synthesis route determination based on qualitative composition of impurities is proposed.
Related Topics
Physical Sciences and Engineering Chemistry Analytical Chemistry
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