Effect of the phase behaviour of the solvent-antisolvent systems on the gas-antisolvent-crystallisation of paracetamol

The influence of the phase behaviour of the solvent-antisolvent system on the process conditions for the gas-antisolvent process is investigated. The two fluids are modelled by the Peng-Robinson equation of state while the dissolved solid is described by a Clapeyron-type approach. Based on the correlation of the ternary system, a liquid-liquid immiscibility region has been found which hinders the proper crystallisation of the solute. A thorough investigation of the binary solvent-antisolvent system by the global phase diagram methods yields a criterion for the proper choice of the solvent. The crucial property turns out to be the distance of the solvent-antisolvent system from the tricritical curve in the global phase diagram.