Aβ deposition is associated with enhanced cortical α-synuclein lesions in Lewy body diseases

Our observations indicate that in cases of PD with dementia, the neocortex is not necessarily involved by LB. Furthermore, the presence of Aβ deposits in the cerebral cortex was associated with extensive α-synuclein lesions and higher levels of insoluble α-synuclein. This suggests that Aβ enhances the development of cortical α-synuclein lesions in cases of PD.