| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 9645163 | Neurobiology of Aging | 2005 | 6 Pages |
Abstract
The effects of the nitric oxide (NO) donor molsidomine on aged rats' cognition were evaluated in two different behavioral tasks: the step-through passive avoidance paradigm and the object recognition test. Post-training injection of molsidomine (at 4 but not at 2Â mg/kg) significantly counteracted the performance deficits displayed by old rats in both the behavioral paradigms. These results support and extend prior findings about the implication of NO in learning and memory mechanisms. In addition, for the first time, a NO donor was found to antagonize age-related memory impairments, suggesting that the integrity of the NO-ergic system may be important in brain aging processes.
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Authors
Nikolaos Pitsikas, Antonello E. Rigamonti, Silvano G. Cella, Nikolaos Sakellaridis, Eugenio E. Muller,