Competition of natural polyamines with dimethylsilyl analogues and monovalent cations in presence of a charged dipalmitoylphosphatidylglycerol monolayer

For the competition experiments, whereas a partial substitution is possible after putrescine and spermine adsorption, it is almost complete after spermine adsorption. Since the number of amino groups of azhepsi and spermine are the same, hydrophobic interactions due to the presence of dimethylsilyl group occur between azhepsi and the alkyl chains of DPPG. This favoured insertion of azhepsi provides a basis for understanding of the action of dimethylsilyl derivatives in the case of an antitumour strategy.