| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 9693953 | Thermochimica Acta | 2005 | 4 Pages |
Abstract
Solid dispersions of silybin and poly(ethylene glycol) (PEG) 6000 were prepared by fusion-cooling. T-wt% and ÎfusHw-wt% diagrams have been constructed by DSC method. A eutectic point with wtsily%Â =Â 33.3 and TmEÂ =Â 324.3Â K was determined. IR spectroscopy and X-ray diffraction results indicates that the spectrum can be regarded as the superposition of those silybin and PEG 6000. There was no significant change in the crystal structure of silybin and PEG 6000 in their solid dispersion formulations. The experimental T-wt% and ÎfusHw-wt% diagrams were fit with fair agreement by Flory-Huggins model.
Related Topics
Physical Sciences and Engineering
Chemical Engineering
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Authors
Wei-Wei Yao, Tong-Chun Bai, Jian-Ping Sun, Cheng-Wen Zhu, Jie Hu, Hua-Li Zhang,