Optic nerve and retinal reflectance changes in response to physiological stimuli

An ocular fundus reflectometer to measure non-invasively the light reflectance changes in response to diffuse flicker stimulation at two wavelengths (569 and 600 nm) simultaneously is presented. Image registration to minimize the effect of involuntary eye motion is described. Two-dimensional maps of reflectance changes of the optic disc and peripapillary retinal tissues in healthy volunteers are presented. These functional maps suggest increases in blood volume during stimulation, with changes in the optic disc as large as 10.7% at 569 nm and 3.5% at 600 nm.