Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9745080 | Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics | 2005 | 19 Pages |
Abstract
The surge of interest in protein kinases as targets for chemotherapeutic intervention in a number of diseases such as cancer and neurodegenerative disorders has stimulated research aimed at determining whether enzymes of this class might also be considered as targets in the context of diseases caused by parasitic protists. Here, we present an overview of recent developments in this field, concentrating (i) on the benefits gained from the availability of genomic databases for a number of parasitic protozoa, (ii) on the emerging field of structure-aided design of inhibitors targeting protein kinases of parasitic protists, (iii) on the concept known as transmission-blockade, whereby kinases implicated in the development of the parasite in their arthropod vector might be targeted to interfere with disease transmission, and (iv) on the possibility of controlling parasitic diseases through the inhibition of host cell protein kinases that are required for the establishment of infection by the parasites.
Keywords
Jun-N-terminal kinaseCaMKpKaGSK3CK1ERKPKGePKHMMCDPKJnkEntamoebaMAPKKCDKNIMAMAPKMAPK/ERK kinaseMitogen activated protein kinase kinaseParasiteInhibitorTrypanosomaToxoplasmaTheileriaDevelopmentSulfadoxine-pyrimethamineMalariaMEKHidden Markov modelknock-outhaemoglobinProtein kinasemitogen activated protein kinasecAMP-dependent protein kinasecGMP-dependent protein kinaseCalcium-dependent protein kinasePlasmodiumcasein kinase 1Drug discoveryChloroquineCalmodulin kinaseextracellular signal-regulated kinasecyclin-dependent kinaseglycogen synthase kinase 3
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Christian Doerig, Oliver Billker, David Pratt, Jane Endicott,