Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9746792 | International Journal of Mass Spectrometry | 2005 | 11 Pages |
Abstract
A combination of hydrogen exchange and mass spectrometry emerged in recent years as a powerful experimental tool capable of probing both structural and dynamic features of proteins. Although its concept is very simple, the interpretation of experimental data is not always straightforward, as a combination of chemical reactions (isotope exchange) and dynamic processes within protein molecules give rise to convoluted exchange patterns. This paper provides a historical background of this technique, candid assessment of its current state and limitations and a discussion of promising recent developments that can result in tremendous improvements and a dramatic expansion of the scope of its applications.
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Igor A. Kaltashov,