Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9748565 | Journal of Chromatography A | 2005 | 10 Pages |
Abstract
A novel silica-bonded stationary phase containing a functionalized resorcinarene selector was prepared by a straightforward synthesis. The complete modification of all resorcinic hydroxyl groups was achieved by reaction with isopropyl isocyanate. The derivatized resorcinarene selector was subsequently immobilized via the four alkenyl chains containing a terminal double bond by a free radical-induced reaction on mercaptopropyl-functionalized silica. A comprehensive characterization of the resulting bonded stationary phase was carried out by solid state NMR, IR and elemental analysis. The resulting selector is defined as a “polar headed” reversed phase since the highly ordered polar carbamate groups of the new stationary phase are located, compared to conventional polar embedded stationary phases, at a greater distance from the silica surface. Thus a new concept is introduced in the field of polar modified reversed-phase HPLC. The properties of the novel stationary phase are demonstrated by comparison with commercially available reversed phases.
Keywords
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Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Alexander Ruderisch, Waldemar Iwanek, Jens Pfeiffer, Gert Fischer, Klaus Albert, Volker Schurig,