| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 9748805 | Journal of Chromatography A | 2005 | 6 Pages |
Abstract
The application of capillary electrophoresis for separation of penicillin V and its impurities was investigated. The phosphate-borate buffer supplemented with sodium dodecyl sulfate (SDS) 20.0Â g/L (69Â mM) and pentanesulfonic acid sodium salt (PS) 2.2Â g/L (12.5Â mM) adjusted to pH 6.3, and current voltage 15Â kV seem to provide optimal conditions for this aim. The resolution between penicillin V and each impurity was very good. The statistical analysis of phenoxymethylpenicillin V assay showed no significant differences between the results obtained by CE and HPLC methods.
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Authors
Genowefa Pajchel, Katarzyna Michalska, Stefan Tyski,