Article ID Journal Published Year Pages File Type
9748828 Journal of Chromatography A 2005 8 Pages PDF
Abstract
The potential for the utilization of GC × GC-time-of-flight (TOF) MS for high-resolution metabolomics studies is discussed, with the implementation of some statistical comparisons for biomarker detection. Metabolite profiles from NZO obese mice versus BL/6 control mice are compared and contrasted using a number of chromatogram comparison routines, including direct chromatogram comparisons, chromatogram subtraction and averaging routines, as well as a method for generating relative weighted peak surface difference chromatograms, and a more conventional Student's t-test statistical approach.
Related Topics
Physical Sciences and Engineering Chemistry Analytical Chemistry
Authors
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