Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9748828 | Journal of Chromatography A | 2005 | 8 Pages |
Abstract
The potential for the utilization of GCÂ ÃÂ GC-time-of-flight (TOF) MS for high-resolution metabolomics studies is discussed, with the implementation of some statistical comparisons for biomarker detection. Metabolite profiles from NZO obese mice versus BL/6 control mice are compared and contrasted using a number of chromatogram comparison routines, including direct chromatogram comparisons, chromatogram subtraction and averaging routines, as well as a method for generating relative weighted peak surface difference chromatograms, and a more conventional Student's t-test statistical approach.
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Robert A. Shellie, Werner Welthagen, Jitka Zrostliková, Joachim Spranger, Michael Ristow, Oliver Fiehn, Ralf Zimmermann,