Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9749028 | Journal of Chromatography A | 2005 | 7 Pages |
Abstract
Rutaecarpine is a quinazolinocarboline alkaloid of the medicinal herb Evodia rutaecarpa and shows a variety of pharmacological effects. Four oxidation metabolites of rutaecarpine were prepared from 3-methylcholanthrene-treated rat liver microsomes. These metabolites had an [MÂ +Â H]+ ion at m/z 304. The structures of metabolites were identified by comparison of their liquid chromatograms and mass, absorbance, and 1H NMR spectra with those of synthetic standards. Rutaecarpine was metabolized by microsomal enzymes to form 3-, 10-, 11-, and 12-hydroxyrutaecarpine. The formation of 10-hydroxyrutaecarpine was highly induced by a cytochrome P450 1A inducer, 3-methylcholanthrene.
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Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Yune-Fang Ueng, Hsi-Jung Yu, Chang-Hsin Lee, Ching Peng, Woan-Ching Jan, Li-Kang Ho, Chieh-Fu Chen, Ming-Jaw Don,