Simultaneous determination of bisphenol-A-diglycidyl ether, bisphenol-F-diglycidyl ether, and their derivatives in oil-in-water and aqueous-based canned foods by high-performance liquid chromatography with fluorescence detection

A gradient reversed-phase liquid chromatography with fluorescence detection method for simultaneous identification and quantification of bisphenol-A-diglycidyl ether (BADGE), bisphenol-F-diglycidyl ether (BFDGE), and their 10 derivatives in food matrixes was developed and validated for the analysis of oil-in-water- and aqueous-based foodstuffs. The method linearity range 0.016-10 ppm which are hundred-fold below and tenfold above the EU restriction at 1 ppm (mg/kg). The method detection limits range 0.72-4.20 ppb and the method quantitation limits range 2.40-14.85 ppb, respectively. The validation data indicate excellent precision, acceptable recovery, and good robustness, all supporting a good potential to further develop the method as a standard method for the determination of migrations from interior can coatings into foodstuffs.