Article ID Journal Published Year Pages File Type
9749267 Journal of Chromatography A 2005 10 Pages PDF
Abstract
The principles, practicability and potential of comprehensive two-dimensional (2D) gas chromatography coupled to a rapid-scanning quadrupole mass spectrometer (GC × GC-qMS) for the analysis of complex flavour mixtures in food, allergens in fragrances and polychlorinated biphenyls (PCBs) were studied. With a scan speed of 10,000 amu/s, monitoring over a mass range of up to 200 atomic mass unit (amu) can be achieved at an acquisition frequency of 33 Hz. Extending this mass range and/or increasing the data acquisition frequency results in a loss of spectral quality. Optimal parameter settings allow, next to unambiguous identification/confirmation of target compounds on the basis of high-quality mass spectra, fully satisfactory quantification (three to four modulations per peak) with linear calibration plots and detection limits in the low-pg level. The potential of time-scheduled data acquisition to increase the effective mass range within one GC × GC run was also explored. The analyses, with baseline separation of the flavours, allergens and PCB target compounds, took less than 30 min.
Related Topics
Physical Sciences and Engineering Chemistry Analytical Chemistry
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