Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9749268 | Journal of Chromatography A | 2005 | 10 Pages |
Abstract
A recently introduced rapid-scanning quadrupole mass spectrometer (qMS) with an electron-capture negative ion (ECNI) option, the Perkin-Elmer Clarus 500, was tested as a detector for comprehensive two-dimensional gas chromatography (GCÂ ÃÂ GC). The parameters influencing the data acquisition rate in the scan mode, such as scan time and inter-scan delay, and in the selected ion monitoring mode, such as dwell time and inter-channel delay, were evaluated. In the scan mode, good-quality mass spectra covering a range of 300Â Da can be obtained at an acquisition rate of 23Â Hz; in selected ion monitoring, an acquisition rate of 90Â Hz can be achieved when monitoring a single ion. Compared with electron ionisation, the use of electron-capture negative ionisation causes no extra peak broadening. As applications, mixtures of polychlorinated n-alkanes (PCAs), polybrominated diphenyl ethers (PBDEs) and polychlorinated dibenzo-p-dioxins (PCDDs) and dibenzofurans (PCDFs) were analysed. The separation of PCAs based on their number of chlorine substituents was confirmed for the first time by using GCÂ ÃÂ GC-ECNI qMS in the scan mode and a significantly improved limit of detection was achieved for BDEs (10-150Â fg injected) and CDD/Fs (10-700Â fg injected) in the selected ion monitoring mode.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
P. Korytár, J. Parera, P.E.G. Leonards, J. de Boer, U.A.Th. Brinkman,