Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9749299 | Journal of Chromatography A | 2005 | 6 Pages |
Abstract
In this paper we describe an analytical method for the determination of p-phenylenediamine (PPDA) in hair dyes. In the adopted methodology the analyte is transformed into the corresponding imine derivative by treatment with benzaldehyde, and then analyzed by gas chromatography (GC) combined to mass spectrometry (MS), operating in SIM conditions. The direct and simultaneous chemical derivatization of the two amino functions of the analyte with benzaldehyde enhances the instrumental responses enabling the use of a sensitive and accurate method. Concentrations of PPDA in a set of commercial hair coloring creams are determined making use of N-benzylidene-4-methylbenzene-amine as a very stable internal standard which is easily prepared by condensation of 4-methylbenzene-amine with benzaldehyde. The regression calibration curves for PPDA in hair dyes are linear within 0.1 ± 25 mg/ml with 0.99 as a typical correlation coefficient.
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Maria Luisa Di Gioia, Antonella Leggio, Adolfo Le Pera, Angelo Liguori, Anna Napoli, Francesca Perri, Carlo Siciliano,