Theoretical study of mesoscopic stochastic mechanism and effects of finite size on cell cycle of fission yeast

Based on a deterministic cell cycle model, the mesoscopic stochastic differential equations are theoretically derived from the biochemical reactions. The effects of the finite cell size on the cell cycle regulation in the wild type and wee1-cdc25Δ double mutant type are numerically studied by virtue of the chemical Langevin equations. (i) When the system is driven only by the internal noise, our numerical results are in qualitative agreement well with some experimental observations and data. (ii) A parameter, which is sensitive to two resettings of M-phase promoting factor to G2, is treated as a stochastic variable, and the system driven only by the external noise for double mutant type is investigated. (iii) When the system is driven by both the internal and external noise, a simple discussion about the combined effect for double mutant type is given. Our results imply some experimental results would be explained by introducing the appropriate internal or external noise into the cell cycle system.