| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 9754460 | Journal of Pharmaceutical and Biomedical Analysis | 2005 | 7 Pages |
Abstract
An impurity present in calcium folinate (N5-formyl-5,6,7,8-tetrahydrofolic calcium salt) active pharmaceutical ingredient (API) was detected by high-performance liquid chromatography (HPLC). Through analysis by HPLC coupled with atmospheric-pressure chemical-ionization mass spectrometry (APCI-MS), a structure for this impurity was postulated and then proved by chemical synthesis.
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Giancarlo Francese, Federica Corana, Olivia Meneghetti, Fabrizio Marazza,