| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 9754470 | Journal of Pharmaceutical and Biomedical Analysis | 2005 | 4 Pages |
Abstract
An isocratic supercritical/subcritical fluid chromatography method for the separation of naproxen enantiomers on the Kromasil CHI-TBB column was investigated. The mobile phase was composed of supercritical CO2 with 2-propanol as modifier. The experimental conditions were temperature 293Â K-323Â K, pressure 9.4Â MPa-21.3Â MPa, and 2-propanol concentration 6%-15% (by mass), respectively. The enthalpic contribution to the overall enantiomer transfer energy was more important than the entropic contribution in the temperature range examined. The preferred operation conditions were 293Â K, 9.4Â MPa, and the concentration of 2-propanol in the mobile phase 11% (by mass).
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Yiwen Yang, Baogen Su, Quanhong Yan, Qilong Ren,