| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 9754502 | Journal of Pharmaceutical and Biomedical Analysis | 2005 | 4 Pages |
Abstract
Electrochemical DNA biosensors can become a powerful tool for the investigation of potent changes on the plasmid DNA structure caused by polymers used as non-viral vectors in gene delivery. Trimethylated chitosan oligomer (TMO) and polyethylenimine (PEI), offering biocompatibility, low immunogenicity and minimal cytotoxicity, are being studied as model non-viral carriers. The information obtained is intended to serve as a basis for developing a new analytical system for the study of the effect of any physically or chemically synthesized polymer on DNA structure.
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
I.Ch. Gherghi, S.Th. Girousi, M. Thanou, A.N. Voulgaropoulos, R. Tzimou-Tsitouridou,