Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9757694 | Chemistry and Physics of Lipids | 2005 | 15 Pages |
Abstract
Our results, therefore show that both the surface-negative charge and the nature of the acidic lipid included in bilayers modulate the activity of phospholipase A1 towards phosphatidylcholine, while the change in lipid hydration or in fluidity of membrane are less critical. These observations may have physiological implications with respect to the rate of degradation of cellular membranes after their lysosomal segregation.
Keywords
Ganglioside GM1DPHLBPACHOLGM1sPLA2MLVmultilamellar vesiclesEDTAethylene-diamine-tetra-acetic acidsphingomyelinphosphatidic acidlysobisphosphatidic acidlarge unilamellar vesiclesDiphenylhexatrieneFluidityLamellar phasephosphatidylinositolphosphatidylcholinephosphatidylglycerolphosphatidylethanolaminePhosphatidylserineSecreted phospholipase A2LUVSUVSurface potentialcholesterolsmall unilamellar vesicles
Related Topics
Physical Sciences and Engineering
Chemistry
Chemistry (General)
Authors
Jocelyne Piret, André Schanck, Sylvie Delfosse, Françoise Van Bambeke, Bellamkonda K. Kishore, Paul M. Tulkens, Marie-Paule Mingeot-Leclercq,