Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9769079 | Carbohydrate Polymers | 2005 | 4 Pages |
Abstract
Three kinds of partially deacetylated chitosan, 90% deacetylated chitosan, 75% deacetylated chitosan and 50% deacetylated chitosan, were prepared from crab chitin by N-deacetylation with 40% (w/w) sodium hydroxide solution for different durations. In order to improve biological activity and solubility, their sulfated derivatives were prepared, and prolyl endopeptidase (PEP) inhibitory activities were investigated. Fifty percent-deacetylated chitosan sulfate (50-CS) exhibited the highest inhibitory activity, and inhibition rate was a dose-dependant. In addition, Dixon plots suggested that 50-CS was act as competitive inhibitor, and the inhibition constant (Ki) was 2.6Â mg/ml.
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Authors
Jae-Young Je, Pyo-Jam Park, Se-Kwon Kim,