| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 9769153 | European Journal of Medicinal Chemistry | 2005 | 24 Pages |
Abstract
Sixty-four new indanones and thiaindanones related to donepezil were synthesized and evaluated in vitro as potential AChE inhibitors. Among them, 11 derivatives were found to inhibit the enzyme in the submicromolar range; the best compound revealed its inhibitory activity with an IC50 in the same range (0.06 μM) than the reference compound, donepezil (IC50 = 0.02 μM).
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Ziad Omran, Thomas Cailly, Elodie Lescot, Jana Sopkova-de Oliveira Santos, Jean-Hugues Agondanou, Vincent Lisowski, Frédéric Fabis, Anne-Marie Godard, Silvia Stiebing, Guillaume Le Flem, Michel Boulouard, François Dauphin, Patrick Dallemagne,